Metagenomic Diagnosis for a Culture-Negative Sample From a Patient With Severe Pneumonia by Nanopore and Next-Generation Sequencing

Metagenomic Diagnosis for a Culture-Negative Sample From a Patient With Severe Pneumonia by Nanopore and Next-Generation Sequencing

Rapid and accurate etiologic diagnosis accelerates targeted antimicrobial therapy. Metagenomic analysis has played a critical role in pathogen identification. In this study, we leveraged the advantages of both the MinION and BGISEQ-500 platforms to make a bacteriologic diagnosis from a culture-negat...

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Bibliographic Details
Main Authors: Kaiying Wang, Peihan Li, Yanfeng Lin, Hongbin Chen, Lang Yang, Jinhui Li, Tingyan Zhang, Qichao Chen, Zhonghong Li, Xinying Du, Yusen Zhou, Peng Li, Hui Wang, Hongbin Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
metagenomic next-generation sequencing (mNGS)
nanopore sequencing
whole genome sequencing
clinical diagnosis
severe pneumonia
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.00182/full

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https://www.frontiersin.org/article/10.3389/fcimb.2020.00182/full

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