A Gene-Set Enrichment and Protein–Protein Interaction Network-Based GWAS with Regulatory SNPs Identifies Candidate Genes and Pathways Associated with Carcass Traits in Hanwoo Cattle

A Gene-Set Enrichment and Protein–Protein Interaction Network-Based GWAS with Regulatory SNPs Identifies Candidate Genes and Pathways Associated with Carcass Traits in Hanwoo Cattle

Non-synonymous SNPs and protein coding SNPs within the promoter region of genes (regulatory SNPs) might have a significant effect on carcass traits. Imputed sequence level data of 10,215 Hanwoo bulls, annotated and filtered to include only regulatory SNPs (450,062 SNPs), were used in a genome-wide a...

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Bibliographic Details
Main Authors: Krishnamoorthy Srikanth, Seung-Hwan Lee, Ki-Yong Chung, Jong-Eun Park, Gul-Won Jang, Mi-Rim Park, Na Yeon Kim, Tae-Hun Kim, Han-Ha Chai, Won Cheoul Park, Dajeong Lim
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Genes
Subjects:
hanwoo
gwas
non-synonymous snp
gene-set enrichment
pathway analysis
marbling
carcass weight
eye muscle area
backfat thickness
imputation
Online Access:https://www.mdpi.com/2073-4425/11/3/316

Internet

https://www.mdpi.com/2073-4425/11/3/316

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