Dynamic alterations of genome and transcriptome in KRAS G13D mutant CRC PDX model treated with cetuximab

Dynamic alterations of genome and transcriptome in KRAS G13D mutant CRC PDX model treated with cetuximab

Abstract Background KRAS mutations have been characterized as the major predictive biomarkers for resistance to cetuximab treatment. However, studies indicate that not all KRAS mutations are associated with equivalent treatment outcomes. KRAS G13D mutations were observed to account for approximately...

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Bibliographic Details
Main Authors: Hangyu Zhang, Liyun Yuan, Lulu Liu, Cong Yan, Jinming Cheng, Qihan Fu, Zhou Tong, Weiqin Jiang, Yi Zheng, Peng Zhao, Guoqing Zhang, Weijia Fang
Format: Article
Language:English
Published: BMC 2020-05-01
Series:BMC Cancer
Subjects:
Colorectal cancer
Cetuximab resistance
Whole-exome sequencing
RNA sequencing
Online Access:http://link.springer.com/article/10.1186/s12885-020-06909-y

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http://link.springer.com/article/10.1186/s12885-020-06909-y

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