The mutational landscape of the oncogenic MZF1 SCAN domain in cancer

The mutational landscape of the oncogenic MZF1 SCAN domain in cancer

SCAN domains in zinc-finger transcription factors are crucial mediators of protein-protein interactions. Up to 240 SCAN-domain encoding genes have been identified throughout the human genome. These include cancer-related genes, such as the myeloid zinc finger 1 (MZF1), an oncogenic transcription fac...

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Bibliographic Details
Main Authors: Mads Nygaard, Thilde Terkelsen, Andre Vidas Olsen, Valentina Sora, Juan Salamanca Viloria, Fabio Rizza, Sanne Bergstrand, Miriam Di Marco, Mette Vistesen, Matteo Tiberti, Matteo Lambrughi, Marja Jaattela, Tuula Kallunki, Elena Papaleo
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Molecular Biosciences
Subjects:
Molecular Dynamics Simulation
Transcription Factors
RNAseq
TCGA
cancer mutations
Saturation mutagenesis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmolb.2016.00078/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmolb.2016.00078/full

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