Exposure to excess phenobarbital negatively influences the osteogenesis of chick embryos

Phenobarbital is an antiepileptic drug that is widely used to treat epilepsy in a clinical setting. However, a long term of phenobarbital administration in pregnant women may produce side effects on embryonic skeletogenesis. In this study, we aim to investigate the mechanism by which phenobarbital t...

Full description

Bibliographic Details
Main Authors: Yu Yan, Xin Cheng, Ren-hao Yang, He Li, Jian-long Chen, Zheng-lai Ma, Guang Wang, Manli Chuai, Xuesong Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00349/full