Lathosterol Oxidase (Sterol C-5 Desaturase) Deletion Confers Resistance to Amphotericin B and Sensitivity to Acidic Stress in Leishmania major

Lathosterol Oxidase (Sterol C-5 Desaturase) Deletion Confers Resistance to Amphotericin B and Sensitivity to Acidic Stress in Leishmania major

Sterols are essential membrane components in eukaryotes, and sterol synthesis inhibitors can have potent effects against pathogenic fungi and trypanosomatids. Understanding the roles of sterols will facilitate the development of new drugs and counter drug resistance. LSO is required for the formatio...

Full description

Bibliographic Details
Main Authors: Yu Ning, Cheryl Frankfater, Fong-Fu Hsu, Rodrigo P. Soares, Camila A. Cardoso, Paula M. Nogueira, Noelia Marina Lander, Roberto Docampo, Kai Zhang
Format: Article
Language:English
Published: American Society for Microbiology 2020-07-01
Series:mSphere
Subjects:
leishmania
amphotericin
drug resistance mechanisms
lipid synthesis
sterols
stress response
Online Access:https://doi.org/10.1128/mSphere.00380-20

Internet

https://doi.org/10.1128/mSphere.00380-20

Similar Items