Hypoxia-Inducible Factor-1α Activity as a Switch for Glioblastoma Responsiveness to Temozolomide

Hypoxia-Inducible Factor-1α Activity as a Switch for Glioblastoma Responsiveness to Temozolomide

RationaleThe activity of the transcription factor, hypoxia-inducible factor (HIF)-1α, is a common driver of a number of the pathways involved in the aggressiveness of glioblastomas (GBMs), and it has been suggested that the reduction in this activity observed, soon after the administration of temozo...

Full description

Bibliographic Details
Main Authors: Alessia Lo Dico, Cristina Martelli, Cecilia Diceglie, Giovanni Lucignani, Luisa Ottobrini
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Oncology
Subjects:
theranostic biomarker
hypoxia-inducible factor-1α silencing
apoptosis
chaperone-mediated autophagy activity
temozolomide responsiveness
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00249/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2018.00249/full

Similar Items