Decreased Efficacy of Doxorubicin Corresponds With Modifications in Lipid Metabolism Markers and Fatty Acid Profiles in Breast Tumors From Obese vs. Lean Mice

Decreased Efficacy of Doxorubicin Corresponds With Modifications in Lipid Metabolism Markers and Fatty Acid Profiles in Breast Tumors From Obese vs. Lean Mice

Breast cancer cells modulate lipid and fatty acid metabolism to sustain proliferation. The role of adipocytes in cancer treatment efficacy remains, however, to be fully elucidated. We investigated whether diet-induced obesity (DIO) affects the efficacy of doxorubicin treatment in a breast tumor-bear...

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Bibliographic Details
Main Authors: Ilze Mentoor, Theo Nell, Zaakiyah Emjedi, Paul J. van Jaarsveld, Louis de Jager, Anna-Mart Engelbrecht
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Oncology
Subjects:
obesity
breast cancer
adipose tissue
fatty acids
treatment efficacy
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00306/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00306/full

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