Astroglial Ca2+-Dependent Hyperexcitability Requires P2Y1 Purinergic Receptors and Pannexin-1 Channel Activation in a Chronic Model of Epilepsy

Astroglial Ca2+-Dependent Hyperexcitability Requires P2Y1 Purinergic Receptors and Pannexin-1 Channel Activation in a Chronic Model of Epilepsy

Astrocytes from the hippocampus of chronic epileptic rats exhibit an abnormal pattern of intracellular calcium oscillations, characterized by an augmented frequency of long lasting spontaneous Ca2+ transients, which are sensitive to purinergic receptor antagonists but resistant to tetrodotoxin. The...

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Bibliographic Details
Main Authors: Mario Wellmann, Carla Álvarez-Ferradas, Carola J. Maturana, Juan C. Sáez, Christian Bonansco
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
kindling
gliotransmission
astrocyte-to-astrocyte signaling
hemichannels
purinergic receptors
epilepsy
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00446/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00446/full

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