Pharmacogenetics of the Central Nervous System—Toxicity and Relapse Affecting the CNS in Pediatric Acute Lymphoblastic Leukemia

Pharmacogenetics of the Central Nervous System—Toxicity and Relapse Affecting the CNS in Pediatric Acute Lymphoblastic Leukemia

Despite improving cure rates in childhood acute lymphoblastic leukemia (ALL), therapeutic side effects and relapse are ongoing challenges. These can also affect the central nervous system (CNS). Our aim was to identify germline gene polymorphisms that influence the risk of CNS events. Sixty single n...

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Bibliographic Details
Main Authors: Judit C. Sági, András Gézsi, Bálint Egyed, Zsuzsanna Jakab, Noémi Benedek, Andishe Attarbaschi, Stefan Köhrer, Jakub Sipek, Lucie Winkowska, Marketa Zaliova, Stavroula Anastasopoulou, Benjamin Ole Wolthers, Susanna Ranta, Csaba Szalai, Gábor T. Kovács, Ágnes F. Semsei, Dániel J. Erdélyi
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
encephalopathy
CNS toxicity
CNS relapse
PRES
genetic polymorphisms
childhood leukemia
Online Access:https://www.mdpi.com/2072-6694/13/10/2333

Internet

https://www.mdpi.com/2072-6694/13/10/2333

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