Deletion of Long Isoform of Eukaryotic Elongation Factor 1Bδ Leads to Audiogenic Seizures and Aversive Stimulus-Induced Long-Lasting Activity Suppression in Mice

Deletion of Long Isoform of Eukaryotic Elongation Factor 1Bδ Leads to Audiogenic Seizures and Aversive Stimulus-Induced Long-Lasting Activity Suppression in Mice

Alternative splicing enables a gene to give rise to diverse protein products. The Eef1d gene produces two isoforms: a short isoform that encodes translation elongation factor 1Bδ (eEF1Bδ1), and a long isoform that encodes the heat shock-responsive transcription factor eEF1BδL. Previously, we found t...

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Bibliographic Details
Main Authors: Taku Kaitsuka, Hiroshi Kiyonari, Aki Shiraishi, Kazuhito Tomizawa, Masayuki Matsushita
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
elongation factor
alternative splicing
audiogenic seizure
fear conditioning
protein synthesis
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00358/full

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00358/full

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