Hepatic Regulator of G Protein Signaling 6 (RGS6) drives non-alcoholic fatty liver disease by promoting oxidative stress and ATM-dependent cell death

Hepatic Regulator of G Protein Signaling 6 (RGS6) drives non-alcoholic fatty liver disease by promoting oxidative stress and ATM-dependent cell death

The pathophysiological mechanism(s) driving non-alcoholic fatty liver disease, the most prevalent chronic liver disease globally, have yet to be fully elucidated. Here, we identify regulator of G protein signaling 6 (RGS6), up-regulated in the livers of NAFLD patients, as a critical mediator of hepa...

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Bibliographic Details
Main Authors: Tarun Mahata, Abhishek Singh Sengar, Madhuri Basak, Kiran Das, Arnab Pramanick, Sumit Kumar Verma, Praveen Kumar Singh, Sayan Biswas, Subhasish Sarkar, Sudipta Saha, Suvro Chatterjee, Madhusudan Das, Adele Stewart, Biswanath Maity
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Redox Biology
Subjects:
RGS proteins
ATM
NAFLD
Steatosis
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721002640

Internet

http://www.sciencedirect.com/science/article/pii/S2213231721002640

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