Sphingosine 1-Phosphate Induces Cyclooxygenase-2/Prostaglandin E2 Expression via PKCα-dependent Mitogen-Activated Protein Kinases and NF-κB Cascade in Human Cardiac Fibroblasts

Sphingosine 1-Phosphate Induces Cyclooxygenase-2/Prostaglandin E2 Expression via PKCα-dependent Mitogen-Activated Protein Kinases and NF-κB Cascade in Human Cardiac Fibroblasts

In the regions of tissue injuries and inflammatory diseases, sphingosine 1-phosphate (S1P), a proinflammatory mediator, is increased. S1P may induce the upregulation of cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) system in various types of cells to exacerbate heart inflammation. However, the de...

Full description

Bibliographic Details
Main Authors: Chien-Chung Yang, Li-Der Hsiao, Mei-Hsiu Su, Chuen-Mao Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Pharmacology
Subjects:
human cardiac fibroblasts
NF-κB
mitogen-activated protein kinases
PKCα
cyclooxygenase-2
sphingosine 1-phosphate
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.569802/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.569802/full

Similar Items