Mutation E48K in PB1 Polymerase Subunit Improves Stability of a Candidate Live Attenuated Influenza B Virus Vaccine

Influenza B virus (IBV) is a major respiratory pathogen of humans, particularly in the elderly and children, and vaccines are the most effective way to control it. In previous work, incorporation of two mutations (E580G, S660A) along with the addition of an HA epitope tag in the PB1 segment of B/Bri...

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Bibliographic Details
Main Authors: Jongsuk Mo, Stivalis Cardenas-Garcia, Jefferson J. S. Santos, Lucas M. Ferreri, C. Joaquín Cáceres, Ginger Geiger, Daniel R. Perez, Daniela S. Rajao
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Vaccines
Subjects:
PB1
Online Access:https://www.mdpi.com/2076-393X/9/7/800