Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2−/−) or obese (ob/ob) mice

Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2−/−) or obese (ob/ob) mice

Reducing triacylglycerol (TAG) in the liver continues to pose a challenge in states of nonalcoholic hepatic steatosis. Monoacylglycerol O-acyltransferase (MOGAT) enzymes convert monoacylglycerol (MAG) to diacylglycerol, a precursor for TAG synthesis, and are involved in a major pathway of TAG synthe...

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Bibliographic Details
Main Authors: Anil K. Agarwal, Katie Tunison, Jasbir S. Dalal, Chi-Liang Eric Yen, Robert V. Jr.Farese, Jay D. Horton, Abhimanyu Garg
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Journal of Lipid Research
Subjects:
monoacylglycerol O-acyltransferase 1
fatty liver
1-acylglycerol-3-phosphate O-acyltransferase 2
lipodystrophy
diabetes
ob/ob
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520354171

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