Immunogenicity evaluation of a rationally designed polytope construct encoding HLA-A*0201 restricted epitopes derived from Leishmania major related proteins in HLA-A2/DR1 transgenic mice: steps toward polytope vaccine.

Immunogenicity evaluation of a rationally designed polytope construct encoding HLA-A*0201 restricted epitopes derived from Leishmania major related proteins in HLA-A2/DR1 transgenic mice: steps toward polytope vaccine.

<h4>Background</h4>There are several reports demonstrating the role of CD8 T cells against Leishmania species. Therefore peptide vaccine might represent an effective approach to control the infection. We developed a rational polytope-DNA construct encoding immunogenic HLA-A2 restricted p...

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Bibliographic Details
Main Authors: Negar Seyed, Tahereh Taheri, Charline Vauchy, Magalie Dosset, Yann Godet, Ali Eslamifar, Iraj Sharifi, Olivier Adotevi, Christophe Borg, Pierre Simon Rohrlich, Sima Rafati
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0108848

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https://doi.org/10.1371/journal.pone.0108848

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