FOXO4-knockdown suppresses oxidative stress-induced apoptosis of early pro-angiogenic cells and augments their neovascularization capacities in ischemic limbs.

FOXO4-knockdown suppresses oxidative stress-induced apoptosis of early pro-angiogenic cells and augments their neovascularization capacities in ischemic limbs.

The effects of therapeutic angiogenesis by intramuscular injection of early pro-angiogenic cells (EPCs) to ischemic limbs are unsatisfactory. Oxidative stress in the ischemic limbs may accelerate apoptosis of injected EPCs, leading to less neovascularization. Forkhead transcription factor 4 (FOXO4)...

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Bibliographic Details
Main Authors: Takaharu Nakayoshi, Ken-Ichiro Sasaki, Hidemi Kajimoto, Hiroshi Koiwaya, Masanori Ohtsuka, Takafumi Ueno, Hidetoshi Chibana, Naoki Itaya, Masahiro Sasaki, Shinji Yokoyama, Yoshihiro Fukumoto, Tsutomu Imaizumi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3963928?pdf=render

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http://europepmc.org/articles/PMC3963928?pdf=render

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