4-Thiazolidinone Derivatives as MMP Inhibitors in Tissue Damage: Synthesis, Biological Evaluation and Docking Studies

4-Thiazolidinone Derivatives as MMP Inhibitors in Tissue Damage: Synthesis, Biological Evaluation and Docking Studies

Nine 2-(1,2-benzothiazol-3-yl)-N-(4-oxo-2-phenyl-1,3-thiazolidin-3-yl)propanamides combining a benzisothiazole and 4-thiazolidinone in one framework were designed and synthesized. The aim of the study was to verify their effectiveness to affect the inflammatory/oxidative process in which free oxygen...

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Bibliographic Details
Main Authors: Matteo Incerti, Lucia Crascì, Paola Vicini, Esin Aki, Ismail Yalcin, Tugba Ertan-Bolelli, Venera Cardile, Adriana Carol Eleonora Graziano, Annamaria Panico
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Molecules
Subjects:
4-thiazolidinones
ORAC assay
metalloproteinase-9
docking study
keratinocytes cultures
nuclear factor-κB
Online Access:http://www.mdpi.com/1420-3049/23/2/415

Internet

http://www.mdpi.com/1420-3049/23/2/415

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