ATXN1 N-terminal region explains the binding differences of wild-type and expanded forms

ATXN1 N-terminal region explains the binding differences of wild-type and expanded forms

Abstract Background Wild-type (wt) polyglutamine (polyQ) regions are implicated in stabilization of protein-protein interactions (PPI). Pathological polyQ expansion, such as that in human Ataxin-1 (ATXN1), that causes spinocerebellar ataxia type 1 (SCA1), results in abnormal PPI. For ATXN1 a larger...

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Bibliographic Details
Main Authors: Sara Rocha, Jorge Vieira, Noé Vázquez, Hugo López-Fernández, Florentino Fdez-Riverola, Miguel Reboiro-Jato, André D. Sousa, Cristina P. Vieira
Format: Article
Language:English
Published: BMC 2019-10-01
Series:BMC Medical Genomics
Subjects:
Protein-protein interaction
Wild-type ATXN1
Expanded ATXN1
Binding interface
Online Access:http://link.springer.com/article/10.1186/s12920-019-0594-4

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http://link.springer.com/article/10.1186/s12920-019-0594-4

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