Apolipoprotein E isoform dependently affects Tat-mediated HIV-1 LTR transactivation

Apolipoprotein E isoform dependently affects Tat-mediated HIV-1 LTR transactivation

Abstract Background Apolipoprotein E (ApoE) is the major carrier protein that mediates the transport and delivery of cholesterol and other lipids in the brain. Three isoforms of ApoE (ApoE2, ApoE3, ApoE4) exist in humans, and their relative expression levels impact HIV-1 infection, HIV-1/AIDS diseas...

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Bibliographic Details
Main Authors: Nabab Khan, Gaurav Datta, Jonathan D. Geiger, Xuesong Chen
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Neuroinflammation
Subjects:
ApoE
HIV-1 Tat
Low-density lipoprotein receptor-related protein 1
ApoE mimetic peptide
HIV-1 LTR transactivation
Online Access:http://link.springer.com/article/10.1186/s12974-018-1129-1

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http://link.springer.com/article/10.1186/s12974-018-1129-1

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