Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma

Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma

Efforts to identify and target glioblastoma (GBM) drivers have primarily focused on receptor tyrosine kinases (RTKs). Clinical benefits, however, have been elusive. Here, we identify an SRY-related box 2 (SOX2) transcriptional regulatory network that is independent of upstream RTKs and capable of dr...

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Bibliographic Details
Main Authors: Dinesh K. Singh, Rahul K. Kollipara, Vamsidara Vemireddy, Xiao-Li Yang, Yuxiao Sun, Nanda Regmi, Stefan Klingler, Kimmo J. Hatanpaa, Jack Raisanen, Steve K. Cho, Shyam Sirasanagandla, Suraj Nannepaga, Sara Piccirillo, Tomoyuki Mashimo, Shan Wang, Caroline G. Humphries, Bruce Mickey, Elizabeth A. Maher, Hongwu Zheng, Ryung S. Kim, Ralf Kittler, Robert M. Bachoo
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
astrocyte
brain
cancer
glioblastoma
oncogene
stem cells
targeted therapy
transcription factor
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716317715

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http://www.sciencedirect.com/science/article/pii/S2211124716317715

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