A Drosophila ortholog of the human MRJ modulates polyglutamine toxicity and aggregation

A Drosophila ortholog of the human MRJ modulates polyglutamine toxicity and aggregation

In the Drosophila eye, proteins with an expanded polyglutamine (polyQ) tract form nuclear and cytoplasmic inclusions and produce cytotoxicity, demonstrated as loss of eye pigmentation and structural integrity. An EP P-element that suppressed the loss of eye pigmentation was inserted 9.7 kb upstream...

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Bibliographic Details
Main Authors: Zahra Fayazi, Srimoyee Ghosh, Susan Marion, Xiankun Bao, Marlene Shero, Parsa Kazemi-Esfarjani
Format: Article
Language:English
Published: Elsevier 2006-11-01
Series:Neurobiology of Disease
Subjects:
MRJ
Drosophila
Neurodegeneration
Huntington’s disease
Polyglutamine
Inclusions
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106001537

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http://www.sciencedirect.com/science/article/pii/S0969996106001537

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