Identification of a selective inhibitor of IDH2/R140Q enzyme that induces cellular differentiation in leukemia cells

Identification of a selective inhibitor of IDH2/R140Q enzyme that induces cellular differentiation in leukemia cells

Abstract Background IDH2/R140Q mutation is frequently detected in acute myeloid leukemia (AML). It contributes to leukemia via accumulation of oncometabolite D-2-HG. Therefore, mutant IDH2 is a promising target for AML. Discovery of IDH2 mutant inhibitors is in urgent need for AML therapy. Methods S...

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Bibliographic Details
Main Authors: Jiao Chen, Jie Yang, Qingyun Wei, Ling Weng, Fei Wu, Yun Shi, Xiaolan Cheng, Xueting Cai, Chunping Hu, Peng Cao
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Cell Communication and Signaling
Subjects:
IDH2/R140Q
Selective inhibitor
Acute myeloid leukemia
Molecular simulation
Cell differentiation
Online Access:http://link.springer.com/article/10.1186/s12964-020-00536-7

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http://link.springer.com/article/10.1186/s12964-020-00536-7

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