Synthesis and Evaluation of Antidepressant Activities of 5-Aryl-4,5-dihydrotetrazolo [1,5-<i>a</i>]thieno[2,3-<i>e</i>]pyridine Derivatives

Synthesis and Evaluation of Antidepressant Activities of 5-Aryl-4,5-dihydrotetrazolo [1,5-<i>a</i>]thieno[2,3-<i>e</i>]pyridine Derivatives

In this study, we synthetized a series of 5-aryl-4,5-dihydrotetrazolo[1,5-<i>a</i>]thieno[2,3-<i>e</i>]pyridine derivatives containing tetrazole and other heterocycle substituents, i.e., triazole, methyltriazole, and triazolone. The forced swim test (FST) and tail suspension...

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Bibliographic Details
Main Authors: Shiben Wang, Hui Liu, Xuekun Wang, Kang Lei, Guangyong Li, Zheshan Quan
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Molecules
Subjects:
synthesis
antidepressant
FST
5-HT
molecular docking studies
Online Access:https://www.mdpi.com/1420-3049/24/10/1857

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https://www.mdpi.com/1420-3049/24/10/1857

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