Ovarian cancer modulates the immunosuppressive function of CD11b+Gr1+ myeloid cells via glutamine metabolism

Ovarian cancer modulates the immunosuppressive function of CD11b+Gr1+ myeloid cells via glutamine metabolism

Objective: Immature CD11b + Gr1+ myeloid cells that acquire immunosuppressive capability, also known as myeloid-derived suppressor cells (MDSCs), are a heterogeneous population of cells that regulate immune responses. Our study's objective was to elucidate the role of ovarian cancer microenviro...

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Bibliographic Details
Main Authors: Mary P. Udumula, Sharif Sakr, Sajad Dar, Ayesha B. Alvero, Rouba Ali-Fehmi, Eman Abdulfatah, Jing Li, Jun Jiang, Amy Tang, Thomas Buekers, Robert Morris, Adnan Munkarah, Shailendra Giri, Ramandeep Rattan
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Molecular Metabolism
Subjects:
Ovarian cancer
CD11b+Gr1+ immunosuppressive cells
Glutamine metabolism
DLST
MDSCs
α-KGDC
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821001174

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http://www.sciencedirect.com/science/article/pii/S2212877821001174

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