Circulating HMGB1 is elevated in veterans with Gulf War Illness and triggers the persistent pro-inflammatory microglia phenotype in male C57Bl/6J mice

Circulating HMGB1 is elevated in veterans with Gulf War Illness and triggers the persistent pro-inflammatory microglia phenotype in male C57Bl/6J mice

Abstract Gulf War Illness (GWI) is a chronic, multi-symptom peripheral and CNS condition with persistent microglial dysregulation, but the mechanisms driving the continuous neuroimmune pathology are poorly understood. The alarmin HMGB1 is an autocrine and paracrine pro-inflammatory signal, but the r...

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Bibliographic Details
Main Authors: Carla Garza-Lombó, Morrent Thang, Hendrik J. Greve, Christen L. Mumaw, Evan J. Messenger, Chandrama Ahmed, Emily Quinn, Kimberly Sullivan, Michelle L. Block
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-021-01517-1

Internet

https://doi.org/10.1038/s41398-021-01517-1

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