FBXO7 sensitivity of phenotypic traits elucidated by a hypomorphic allele.

FBXO7 sensitivity of phenotypic traits elucidated by a hypomorphic allele.

FBXO7 encodes an F box containing protein that interacts with multiple partners to facilitate numerous cellular processes and has a canonical role as part of an SCF E3 ubiquitin ligase complex. Mutation of FBXO7 is responsible for an early onset Parkinsonian pyramidal syndrome and genome-wide associ...

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Main Authors: Carmen Ballesteros Reviriego, Simon Clare, Mark J Arends, Emma L Cambridge, Agnieszka Swiatkowska, Susana Caetano, Bushra Abu-Helil, Leanne Kane, Katherine Harcourt, David A Goulding, Diane Gleeson, Edward Ryder, Brendan Doe, Jacqueline K White, Louise van der Weyden, Gordon Dougan, David J Adams, Anneliese O Speak
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0212481

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https://doi.org/10.1371/journal.pone.0212481

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