Streamlined computational pipeline for genetic background characterization of genetically engineered mice based on next generation sequencing data

Streamlined computational pipeline for genetic background characterization of genetically engineered mice based on next generation sequencing data

Abstract Background Genetically engineered mice (GEM) are essential tools for understanding gene function and disease modeling. Historically, gene targeting was first done in embryonic stem cells (ESCs) derived from the 129 family of inbred strains, leading to a mixed background or congenic mice whe...

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Bibliographic Details
Main Authors: C. Farkas, F. Fuentes-Villalobos, B. Rebolledo-Jaramillo, F. Benavides, A. F. Castro, R. Pincheira
Format: Article
Language:English
Published: BMC 2019-02-01
Series:BMC Genomics
Subjects:
Sequencing
Congenic mouse
Knockout mouse
Genomic variation
Genetic interactions
Modifier genes
Online Access:http://link.springer.com/article/10.1186/s12864-019-5504-9

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http://link.springer.com/article/10.1186/s12864-019-5504-9

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