Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases

Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases

Excitotoxicity is a phenomenon that describes the toxic actions of excitatory neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of glutamate receptors starts a cascade of neurotoxicity that ultimately leads to the loss of neuronal function and cell death. In this...

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Bibliographic Details
Main Authors: Adam Armada-Moreira, Joana I. Gomes, Carolina Campos Pina, Oksana K. Savchak, Joana Gonçalves-Ribeiro, Nádia Rei, Sara Pinto, Tatiana P. Morais, Robertta Silva Martins, Filipa F. Ribeiro, Ana M. Sebastião, Vincenzo Crunelli, Sandra H. Vaz
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
excitotoxicity
astrocytes
NMDA receptors
calcium signaling
neurodegenerative diseases
oxidative stress
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00090/full

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https://www.frontiersin.org/article/10.3389/fncel.2020.00090/full

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