Tanshinone IIA regulates human AML cell proliferation, cell cycle, and apoptosis through miR-497-5p/AKT3 axis

Tanshinone IIA regulates human AML cell proliferation, cell cycle, and apoptosis through miR-497-5p/AKT3 axis

Abstract Background The roots of Salvia miltiorrhiza are used in traditional Chinese medicine (TCM) and have high medicinal value. Tanshinone IIA (Tan IIA) is the active ingredient of Salvia miltiorrhiza which can inhibit the growth of acute leukemia cell lines in vitro, although the mechanism remai...

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Bibliographic Details
Main Authors: Zi-Yuan Nie, Ming-Hui Zhao, Bao-Qian Cheng, Rong-Fang Pan, Tian-Rui Wang, Yan Qin, Xue-Jun Zhang
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Cancer Cell International
Subjects:
Tanshinone IIA
Acute myeloid leukemia
Proliferation
Apoptosis
miR-497-5p
AKT3
Online Access:http://link.springer.com/article/10.1186/s12935-020-01468-5

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http://link.springer.com/article/10.1186/s12935-020-01468-5

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