Repositioning the Sm-Binding Site in <i>Saccharomyces cerevisiae</i> Telomerase RNA Reveals RNP Organizational Flexibility and Sm-Directed 3′-End Formation

Telomerase RNA contains a template for synthesizing telomeric DNA and has been proposed to act as a flexible scaffold for holoenzyme protein subunits in the RNP. In <i>Saccharomyces cerevisiae</i>, the telomerase RNA, TLC1, is bound by the Sm<sub>7</sub> protein complex, whic...

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Bibliographic Details
Main Authors: Evan P. Hass, David C. Zappulla
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Non-Coding RNA
Subjects:
Online Access:https://www.mdpi.com/2311-553X/6/1/9