Dissolution Advantage of Nitazoxanide Cocrystals in the Presence of Cellulosic Polymers

Dissolution Advantage of Nitazoxanide Cocrystals in the Presence of Cellulosic Polymers

The effect of hydroxypropyl methylcellulose (HPMC) and methylcellulose (Methocel<sup>&#174;</sup> 60 HG) on the dissolution behavior of two cocrystals derived from nitazoxanide (NTZ), viz., nitazoxanide-glutaric acid (NTZ-GLU, 1:1) and nitazoxanide-succinic acid (NTZ-SUC, 2:1), was e...

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Bibliographic Details
Main Authors: Reynaldo Salas-Zúñiga, Christian Rodríguez-Ruiz, Herbert Höpfl, Hugo Morales-Rojas, Obdulia Sánchez-Guadarrama, Patricia Rodríguez-Cuamatzi, Dea Herrera-Ruiz
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Pharmaceutics
Subjects:
nitazoxanide
cocrystals
multicomponent crystals
dissolution behavior
supersaturated formulations
crystallization inhibitors
drug-polymer interactions
Online Access:https://www.mdpi.com/1999-4923/12/1/23

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https://www.mdpi.com/1999-4923/12/1/23

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