High-throughput drug screening reveals Pyrvinium pamoate as effective candidate against pediatric MLL-rearranged acute myeloid leukemia

High-throughput drug screening reveals Pyrvinium pamoate as effective candidate against pediatric MLL-rearranged acute myeloid leukemia

Pediatric MLL-rearranged acute myeloid leukemia (AML) has a generally unfavorable outcome, primarily due to relapse and drug resistance. To overcome these difficulties, new therapeutic agents are urgently needed. Yet, implementing novel drugs for clinical use is a time-consuming, laborious, costly a...

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Bibliographic Details
Main Authors: Priscilla Wander, Susan T.C.J.M. Arentsen-Peters, Sandra S. Pinhanҫos, Bianca Koopmans, M.Emmy M. Dolman, Rijndert Ariese, Frank L. Bos, Patricia Garrido Castro, Luke Jones, Pauline Schneider, Miriam Guillen Navarro, Jan J. Molenaar, Anne C. Rios, C. Michel Zwaan, Ronald W. Stam
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Translational Oncology
Subjects:
High-throughput drug library screen
Pyrvinium pamoate
MLL-rearranged AML
Pediatric acute myeloid leukemia
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321000401

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http://www.sciencedirect.com/science/article/pii/S1936523321000401

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