Androgen receptor (AR) antagonism triggers acute succinate‐mediated adaptive responses to reactivate AR signaling

Androgen receptor (AR) antagonism triggers acute succinate‐mediated adaptive responses to reactivate AR signaling

Abstract Treatment‐induced adaptive pathways converge to support androgen receptor (AR) reactivation and emergence of castration‐resistant prostate cancer (PCa) after AR pathway inhibition (ARPI). We set out to explore poorly defined acute adaptive responses that orchestrate shifts in energy metabol...

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Bibliographic Details
Main Authors: Neetu Saxena, Eliana Beraldi, Ladan Fazli, Syam Prakash Somasekharan, Hans Adomat, Fan Zhang, Chidi Molokwu, Anna Gleave, Lucia Nappi, Kimberly Nguyen, Pavn Brar, Nicholas Nikesitch, Yuzhuo Wang, Colin Collins, Poul H Sorensen, Martin Gleave
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:EMBO Molecular Medicine
Subjects:
Androgen receptor
Hsp27
prostate cancer
succinate dehydrogenase
succinate
Online Access:https://doi.org/10.15252/emmm.202013427

Internet

https://doi.org/10.15252/emmm.202013427

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