Natural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivity.

Natural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivity.

The Vif protein of HIV-1 allows virus replication by degrading several members of the host-encoded APOBEC3 family of DNA cytosine deaminases. Polymorphisms in both host APOBEC3 genes and the viral vif gene have the potential to impact the extent of virus replication among individuals. The most genet...

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Bibliographic Details
Main Authors: Eric W Refsland, Judd F Hultquist, Elizabeth M Luengas, Terumasa Ikeda, Nadine M Shaban, Emily K Law, William L Brown, Cavan Reilly, Michael Emerman, Reuben S Harris
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-11-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4238949?pdf=render

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http://europepmc.org/articles/PMC4238949?pdf=render

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