DNA plasticity and damage in amyotrophic lateral sclerosis

DNA plasticity and damage in amyotrophic lateral sclerosis

The pathophysiology of amyotrophic lateral sclerosis (ALS) is particularly challenging due to the heterogeneity of its clinical presentation and the diversity of cellular, molecular and genetic peculiarities involved. Molecular insights unveiled several novel genetic factors to be inherent in both f...

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Bibliographic Details
Main Authors: Diane Penndorf, Otto W Witte, Alexandra Kretz
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Neural Regeneration Research
Subjects:
amyotrophic lateral sclerosis; DNA damage and repair; extrachromosomal circular DNA; microDNA; nuclear pore complex; SOD1 mutations; TDP-43 pathology; transposable elements
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=2;spage=173;epage=180;aulast=Penndorf

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=2;spage=173;epage=180;aulast=Penndorf

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