Optimization of Critical Hairpin Features Allows miRNA-based Gene Knockdown Upon Single-copy Transduction

Optimization of Critical Hairpin Features Allows miRNA-based Gene Knockdown Upon Single-copy Transduction

Gene knockdown using micro RNA (miRNA)-based vector constructs is likely to become a prominent gene therapy approach. It was the aim of this study to improve the efficiency of gene knockdown through optimizing the structure of miRNA mimics. Knockdown of two target genes was analyzed: CCR5 and green...

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Bibliographic Details
Main Authors: Renier Myburgh, Ophélie Cherpin, Erika Schlaepfer, Hubert Rehrauer, Roberto F Speck, Karl-Heinz Krause, Patrick Salmon
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Molecular Therapy: Nucleic Acids
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116303444

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http://www.sciencedirect.com/science/article/pii/S2162253116303444

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