E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points

E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points

Proteolysis-targeting chimeras (PROTACs) have received tremendous attention as a new and exciting class of therapeutic agents that promise to significantly impact drug discovery. These bifunctional molecules consist of a target binding unit, a linker, and an E3 ligase binding moiety. The chemically-...

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Bibliographic Details
Main Authors: Aleša Bricelj, Christian Steinebach, Robert Kuchta, Michael Gütschow, Izidor Sosič
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Chemistry
Subjects:
bifunctional molecules
cereblon
drug synthesis
E3 ligase ligands
linker attachment
PROTACs
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.707317/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2021.707317/full

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