Axin phosphorylation in both Wnt-off and Wnt-on states requires the tumor suppressor APC.
The aberrant activation of Wnt signal transduction initiates the development of 90% of colorectal cancers, the majority of which arise from inactivation of the tumor suppressor Adenomatous polyposis coli (APC). In the classical model for Wnt signaling, the primary role of APC is to act, together wit...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-02-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC5800574?pdf=render |