GC1qR Cleavage by Caspase-1 Drives Aerobic Glycolysis in Tumor Cells

GC1qR Cleavage by Caspase-1 Drives Aerobic Glycolysis in Tumor Cells

Self-sustained cell proliferation constitutes one hallmark of cancer enabled by aerobic glycolysis which is characterized by imbalanced glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) activity, named the Warburg effect. The C1q binding protein (C1QBP; gC1qR) is pivotal for mitochondr...

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Bibliographic Details
Main Authors: Annika Sünderhauf, Annika Raschdorf, Maren Hicken, Heidi Schlichting, Franziska Fetzer, Ann-Kathrin Brethack, Sven Perner, Claudia Kemper, Berhane Ghebrehiwet, Christian Sina, Stefanie Derer
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Oncology
Subjects:
aerobic glycolysis
gC1qR
inflammasome
mitochondria
OXPHOS
caspase-1
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.575854/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.575854/full

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