ERK and ROCK functionally interact in a signaling network that is compensationally upregulated in Spinal Muscular Atrophy

ERK and ROCK functionally interact in a signaling network that is compensationally upregulated in Spinal Muscular Atrophy

Spinal Muscular Atrophy (SMA) is a motoneuron disease caused by low levels of functional survival of motoneuron protein (SMN). Molecular disease mechanisms downstream of functional SMN loss are still largely unknown. Previous studies suggested an involvement of Rho kinase (ROCK) as well as the extra...

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Bibliographic Details
Main Authors: Niko Hensel, Svetlana Baskal, Lisa Marie Walter, Hella Brinkmann, Manuela Gernert, Peter Claus
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Neurobiology of Disease
Subjects:
Spinal Muscular Atrophy
Motoneuron disease
Signaling
Rho kinase
ERK
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117302152

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http://www.sciencedirect.com/science/article/pii/S0969996117302152

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