The Ubiquitin E3 Ligase Parkin Inhibits Innate Antiviral Immunity Through K48-Linked Polyubiquitination of RIG-I and MDA5

The Ubiquitin E3 Ligase Parkin Inhibits Innate Antiviral Immunity Through K48-Linked Polyubiquitination of RIG-I and MDA5

Innate immunity is the first-line defense against antiviral or antimicrobial infection. RIG-I and MDA5, which mediate the recognition of pathogen-derived nucleic acids, are essential for production of type I interferons (IFN). Here, we identified mitochondrion depolarization inducer carbonyl cyanide...

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Bibliographic Details
Main Authors: Lang Bu, Huan Wang, Panpan Hou, Shuting Guo, Miao He, Jingshu Xiao, Ping Li, Yongheng Zhong, Penghui Jia, Yuanyuan Cao, Guanzhan Liang, Chenwei Yang, Lang Chen, Deyin Guo, Chun-Mei Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
parkin
mitophagy
polyubiquitination
RIG-I
MDA5
innate immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01926/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01926/full

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