Pancreatic cancer-initiating cell exosome message transfer into noncancer-initiating cells: the importance of CD44v6 in reprogramming

Pancreatic cancer-initiating cell exosome message transfer into noncancer-initiating cells: the importance of CD44v6 in reprogramming

Abstract Background Cancer-initiating cell (CIC) exosomes (CIC-TEX) are suggested reprogramming Non-CIC. Mode of message transfer and engagement of CIC-markers being disputed, we elaborated the impact of CD44v6 and Tspan8 on the response of Non-CIC. Methods Non-metastasizing CD44v6- and Tspan8-knock...

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Bibliographic Details
Main Authors: Zhe Wang, Hanxue Sun, Jan Provaznik, Thilo Hackert, Margot Zöller
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
CD44v6
Tspan8
Pancreatic cancer stem cells
Exosome biogenesis
Exosome message transfer
Non-cancer stem cell reprogramming
Online Access:http://link.springer.com/article/10.1186/s13046-019-1129-8

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http://link.springer.com/article/10.1186/s13046-019-1129-8

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