Comparative intra-articular gene transfer of seven adeno-associated virus serotypes reveals that AAV2 mediates the most efficient transduction to mouse arthritic chondrocytes.

Comparative intra-articular gene transfer of seven adeno-associated virus serotypes reveals that AAV2 mediates the most efficient transduction to mouse arthritic chondrocytes.

Osteoarthritis (OA) is the most common arthropathy, characterized by progressive degeneration of the articular cartilage. Currently, there are no disease-modifying approaches for OA treatment. Adeno-associated virus (AAV)-mediated gene therapy has recently become a potential treatment for OA due to...

Full description

Bibliographic Details
Main Authors: Quan Chen, Huan Luo, Chengcong Zhou, Huan Yu, Sai Yao, Fangda Fu, Rebecca Seeley, Xing Ji, Yanping Yang, Peifeng Chen, Hongting Jin, Peijian Tong, Di Chen, Chengliang Wu, Weibin Du, Hongfeng Ruan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0243359

Internet

https://doi.org/10.1371/journal.pone.0243359

Similar Items