Yeast Cth2 protein represses the translation of ARE-containing mRNAs in response to iron deficiency.

In response to iron deficiency, the budding yeast Saccharomyces cerevisiae undergoes a metabolic remodeling in order to optimize iron utilization. The tandem zinc finger (TZF)-containing protein Cth2 plays a critical role in this adaptation by binding and promoting the degradation of multiple mRNAs...

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Bibliographic Details
Main Authors: Lucía Ramos-Alonso, Antonia María Romero, Maria Àngel Soler, Ana Perea-García, Paula Alepuz, Sergi Puig, María Teresa Martínez-Pastor
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-06-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC6023232?pdf=render