Cancer-derived exosomal TRIM59 regulates macrophage NLRP3 inflammasome activation to promote lung cancer progression

Cancer-derived exosomal TRIM59 regulates macrophage NLRP3 inflammasome activation to promote lung cancer progression

Abstract Background Exosomes are emerging as important mediators of the cross-talk between tumor cells and the microenvironment. The communication between tumor-derived exosomes and macrophages has a critical role in facilitating tumor progression. However, the mechanisms by which exosomes modulate...

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Bibliographic Details
Main Authors: Manman Liang, Xingwu Chen, Lijing Wang, Lilong Qin, Hanli Wang, Zhengui Sun, Wenying Zhao, Biao Geng
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Lung cancer
Exosomes
Macrophages
TRIM59
ABHD5
NLRP3
Online Access:http://link.springer.com/article/10.1186/s13046-020-01688-7

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http://link.springer.com/article/10.1186/s13046-020-01688-7

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