The effects of secondary iron overload and iron chelation on a radiation-induced acute myeloid leukemia mouse model

The effects of secondary iron overload and iron chelation on a radiation-induced acute myeloid leukemia mouse model

Abstract Background Patients with myelodysplastic syndrome (MDS) require chronic red blood cell (RBC) transfusion due to anemia. Multiple RBC transfusions cause secondary iron overload and subsequent excessive generation of reactive oxygen species (ROS), which leads to mutations, cell death, organ f...

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Bibliographic Details
Main Authors: Lap Shu Alan Chan, Lilly ChunHong Gu, Richard A. Wells
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Cancer
Subjects:
Secondary iron overload
Iron chelation
Radiation induced acute myeloid leukemia
Leukemogenesis
Myelodysplastic syndrome
Online Access:https://doi.org/10.1186/s12885-021-08259-9

Internet

https://doi.org/10.1186/s12885-021-08259-9

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