Altering Residue 134 Confers an Increased Substrate Range of Alkylated Nucleosides to the E. coli OGT Protein

Altering Residue 134 Confers an Increased Substrate Range of Alkylated Nucleosides to the E. coli OGT Protein

O6-Alkylguanine-DNA alkyltransferases (AGTs) are proteins responsible for the removal of mutagenic alkyl adducts at the O6-atom of guanine and O4-atom of thymine. In the current study we set out to understand the role of the Ser134 residue in the Escherichia coli AGT variant OGT on substrate discrim...

Full description

Bibliographic Details
Main Authors: Nadia M. Schoonhoven, Derek K. O’Flaherty, Francis P. McManus, Lauralicia Sacre, Anne M. Noronha, M. Judith Kornblatt, Christopher J. Wilds
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:Molecules
Subjects:
Bioorganic molecules
modified oligonucleotides
DNA repair
substrate specificity
mutagenesis
homology modeling
DNA interstrand cross-link
Online Access:https://www.mdpi.com/1420-3049/22/11/1948

Internet

https://www.mdpi.com/1420-3049/22/11/1948

Similar Items