In Vivo Microdialysis of Endogenous and <sup>13</sup>C-labeled TCA Metabolites in Rat Brain: Reversible and Persistent Effects of Mitochondrial Inhibition and Transient Cerebral Ischemia

In Vivo Microdialysis of Endogenous and <sup>13</sup>C-labeled TCA Metabolites in Rat Brain: Reversible and Persistent Effects of Mitochondrial Inhibition and Transient Cerebral Ischemia

Cerebral micro-dialysis allows continuous sampling of extracellular metabolites, including glucose, lactate and pyruvate. Transient ischemic events cause a rapid drop in glucose and a rise in lactate levels. Following such events, the lactate/pyruvate (L/P) ratio may remain elevated for a prolonged...

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Bibliographic Details
Main Authors: Jesper F. Havelund, Kevin H. Nygaard, Troels H. Nielsen, Carl-Henrik Nordström, Frantz R. Poulsen, Nils. J. Færgeman, Axel Forsse, Jan Bert Gramsbergen
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Metabolites
Subjects:
<sup>13</sup>c-labeled succinate
cerebral ischemia
energy metabolism
endothelin-1
lc-ms
malonate
micro-dialysis
mitochondrial dysfunction
reperfusion
tricarboxylic acid cycle
Online Access:https://www.mdpi.com/2218-1989/9/10/204

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https://www.mdpi.com/2218-1989/9/10/204

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