The Bispidinone Derivative 3,7-Bis-[2-(<i>S</i>)-amino-3-(1<i>H</i>-indol-3-yl)-propionyl]-1,5-diphenyl-3,7-diazabicyclo[3.3.1]nonan-9-one Dihydrochloride Induces an Apoptosis-Mediated Cytotoxic Effect on Pancreatic Cancer Cells In Vitro

The Bispidinone Derivative 3,7-Bis-[2-(<i>S</i>)-amino-3-(1<i>H</i>-indol-3-yl)-propionyl]-1,5-diphenyl-3,7-diazabicyclo[3.3.1]nonan-9-one Dihydrochloride Induces an Apoptosis-Mediated Cytotoxic Effect on Pancreatic Cancer Cells In Vitro

Pancreatic cancer (PC) is a complex, heterogeneous disease with a dismal prognosis. Current therapies have failed to improve survival outcomes, urging the need for discovery of novel targeted treatments. Bispidinone derivatives have yet to be investigated as cytotoxic agents against PC cells. The cy...

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Bibliographic Details
Main Authors: Melanie J. Predebon, Danielle R. Bond, Joshua Brzozowski, Helen Jankowski, Fiona Deane, Mark Tarleton, Aron A. Shaw, Adam McCluskey, Michael C. Bowyer, Judith Weidenhofer, Christopher J. Scarlett
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Molecules
Subjects:
Pancreatic cancer
bispidinone
cytotoxic
in vitro
apoptosis
drug development
Online Access:https://www.mdpi.com/1420-3049/24/3/524

Internet

https://www.mdpi.com/1420-3049/24/3/524

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